Most people in sub-continent suffer heart disease

Date of Publication:

application-pdfheart disease,neck and low back pain

Dhaka, Jan 31 (UNB) – Two medical experts from Singapore Saturday said that most of the people in this sub-continent suffered from heart disease and back pain for having bad-gene.
“Bad-gene is one of the major causes of heart disease and back pain in this sub-continent.Though disciplinary life style and exercise help control the disease but no possibility of healing
the disease”, they told at an arranged interview at a hotel here.The interview on “Heart Diseases and Neck and Back Pain” organised by Parkway Health,
Singapore, which owns and operates Mount Elizabeth Hospital, Gleneagles Hospital and East Shore Hospital.Dr. Saw Huat Seong, senior consultant of cardiothoracic surgeon of Mount Elizabeth Hospital,
and Dr. Timothy Lee, senior consultant of Neuro-Spinal Surgeon of Gleneagles Hospital, delivered their lecture on heart disease and neck and back pain at the programme.
Dr Lee said that about 95 percent people are not aware of the disease of neck and low back pain, which are mainly caused by excessive movement of their neck and degeneration.
Some exercises relating to movement of neck or back portion excessively like swimming or throwing are not good for health, he observed. About the reason of heart diseases, Dr Seong said life style or bad food habit are not only reason
of heart disease. The main reason of the people of this sub-continent is bad-gene. Asked about the medical facilities of heart disease in Bangladesh, Dr Seong said Bangladesh
lack of specialized and skilled physicians and their helping hands like nurses. “You have vast population. So, one or slightly more than that might go abroad for better treatment
in such critical cases,” Seong said. He informed that patients even from Singapore often go to other developed countries for better treatment.

Effect of a new computed tomographic image transfer system
on management of referrals to a regional neurosurgical service.

Date of Publication:

Lee T, Latham J, Kerr RS, Kaar G, Teddy PJ, Dobson D, Anslow P.

Source: TheLancet

Department of Neurosurgery, Radcliffe Infirmary, Oxford, UK. Abstract A computed tomographic image transfer system (‘Image Link’) was used to link scanners within the Oxford region, UK, to the regional neurosurgical service. 100 consecutive neurosurgical referrals were examined by this system; 43% of the emergency referrals did not require transfer, 31% were transferred electively, and 26% urgently.

Most of the patients defined as potentially hazardous for transfer (10/11) did not require neurosurgical intervention. The delay by the use of the system was negligible and early detection of intracranial haematoma contributed to good outcome in some head injured patients. Overall, 3,170 miles of ambulance journey were avoided. Use of image link has led to substantial improvements in management of neurosurgical emergency referrals, cost-effectiveness of neurosurgical and ambulance facilities, and interhospital communication between doctors.

PMID: 1975285 [PubMed – indexed for MEDLINE]

Controlled release of human immunoglobulin G. 1. Release kinetics studies

Date of Publication:

Chi-Hwa Wang, Kamalesh Sengothi, Timothy Lee

Article first published online: 12 JUN 2000

Source:Wiley Online Library

DOI: 10.1021/js9803407 Abstract The release of human immunoglobulin G (IgG) using ethylene–vinyl acetate copolymer (EVAc) as a polymer carrier was studied by fabricating them into two commercially available dosage forms: slab and microsphere. A first-order flux decay model and two hierarchical models concerned with the mass transfer coefficient on the slab surface were used to describe the mechanism of release kinetics and the results compared. These models gave insight to some of the important physical parameters of drug release such as the diffusion coefficient, time constant of release, and initial flux.It was found that the release mechanism varies with time, and hence no single model can be used to predict the release profile for the entire period of study. A controlled release study by matrix coating was also done. The results obtained were utilized to examine the suitability of a particular dosage form (matrix geometry) of IgG for clinical applications. The release data compared with the standard methods of IgG therapy proves localized drug delivery to be a major boon for immunodeficient patients.

A bilateral Parkinson model in non-human primates by
sequential intracarotid MPTP injection

Date of Publication:

T K Y Lee, R Chau, S K Leong


ABSTRACT The present understanding of the anatomy of the basal ganglia has been updated. Recent work has produced a primate model of Parkinson’s disease for study of its pathogenesis and treatment. In the last two decades, administration of dopamine agonist has been the mainstay of treatment of Parkinson’s disease in the humans. However, recent use of dopamine-rich tissue such as adrenal gland or human foetal cells is opening up a new frontier for the treatment of more severe Parkinsonism. Nevertheless, there is still much to be learned at the basic neuroscience level before such procedure could be used widely in clinical practice.

Microchip implants on the anterior sacral roots in patients
with spinal trauma: does it improve bowel function?

Date of Publication:

Chia YW, Lee TK, Kour NW, Tung KH, Tan ES.


Department of Surgery, National University Hospital, Singapore, Singapore.
PURPOSE:This study evaluated the effect of anterior sacral roots stimulator implants on bowel function of patients with spinal cord trauma.

METHOD:Eight patients with spinal cord injury and constipation had anterior sacral roots stimulator implants inserted for concomitant bladder dysfunction. Questionnaires on bowel function and anorectal manometry tests were given before and after insertion of the implants.

RESULTS:Six patients achieved improvement in bowel function. Four of these patients could defecate spontaneously following stimulation. Two patients had no improvement in bowel function. Anorectal manometry studies showed a negative rectoanal pressure difference at the time of stimulation. All patients were unable to defecate during stimulation. Positive rectoanal pressure difference was recorded in the six patients who had improved bowel function. This may be attributable to the slower relaxation of the smooth rectal muscle compared with the easily fatigable striated external anal sphincter.

CONCLUSION:Anterior sacral roots stimulator implants can improve bowel function in patients with spinal cord trauma.

PMID: 8646959 [PubMed – indexed for MEDLINE]